A man had died in a head on crash involving a truck and a car near the Pilbara town of Karratha.

Police say the incident happened just after 5:00 pm yesterday afternoon on the North West Coastal Highway, about a kilometre west of the Madigan Road intersection.

The male driver of the car died at the scene.

The truck driver was taken to Nickol Bay Hospital for treatment, his condition is unknown at this stage.

Major Crash officers will investigate.