Two men have been killed and two other people have been critically injured in a crash on the Hume freeway at Winton, near Benalla, in north-eastern Victoria.

Police believe the men in their 30s died when the van they were passengers in veered off the road and rolled several times about 11:00pm (AEDT).

Two other passengers have been flown to hospital.

The driver and another passenger have been taken to local hospitals for treatment.

Police are investigating the circumstances of the crash.

The deaths take the Easter road toll to five.

In total, 66 people have been killed on Victoria's roads this year, compared to 77 at the same time last year.