Port Adelaide mayor Gary Johanson says a local fertiliser plant should be moved after yesterday's deadly explosion in Texas.
A development at Port Adelaide near the Incitec Pivot plant was put on hold in 2011 after SafeWork SA found that ammonium nitrate stored at the site could explode.
Mr Johanson says he understands the chemicals are currently not being stored there, but could be in the future under its licence conditions.
The company indicated last year it might shift from its Port Adelaide premises if taxpayers helped to fund the move.
Mr Johanson wants the State Government to step in and close the site.
"The blast zone that they implemented, or stated that no residential development should occur within, was something like 900 metres," he said.
"When you look at news reports of that fertiliser works going up, I believe they stated the effect was felt as far away as 80 kilometres. I think the time is right to fully support the EPA and SafeWork in their judgment.
"While the licence exists that allows it to store such chemicals there's always a chance that those chemicals can be stored there again in the future.
"Let's look towards this industry which is an important industry, see if it can be moved, potentially with government assistance to a safer location, safer for the people of Port Adelaide in particular if there was to be some form of a catastrophe."
Authorities in Texas have confirmed the huge blast at the fertiliser plant at West, south of Dallas, resulted in deaths.
Up to 70 homes and buildings were destroyed in a five-block radius and about 160 people were injured.