ROSMALEN, Netherlands (AP) — John Isner led an exodus of seeded players at the rain-interrupted Topshelf Open when he crashed out 6-7 (3), 6-3, 6-4 to Evgeny Donskoy on Monday.

The third-seeded Isner was shown the exit with No. 6 Marcos Baghdatis of Cyprus, No. 7 Victor Hanescu of Romania, and No. 8 Daniel Gimeno-Traver of Spain.

Neither Isner nor Donskoy could break serve in the opening set that Isner edged in a tiebreak but Donskoy hit back quickly, breaking Isner's first service game of the second set and breaking once more in the final set to book a place in the second round of the Wimbledon warmup.

Earlier, Baghdatis was a set down to Carlos Berlocq and trailing 2-1 in the second when rain forced the players off court. The Cypriot could not use the pause to regroup and lost 6-2, 6-4.

Hanescu lost 6-4, 6-3 to Guillermo Garcia-Lopez and Andrey Kuznetsov beat Gimeno-Traver 7-6 (4), 6-3.

In the women's event, third-seeded Carla Suarez Navarro advanced with a 6-3, 6-2 win over Johanna Larsson and Lauren Davis of the United States ousted Andrea Hlavackova 6-3, 6-4.

Second-seeded Dominika Cibulkova was 2-1 up in the third set against Lourdes Dominguez Lino when play was suspended by the rain. The Slovak held on to take the final set to advance 6-1, 6-7 (5), 7-6.

Defending champion and losing Roland Garros finalist David Ferrer was opening his campaign on Tuesday against Xavier Malisse and 2011 women's tournament winner Roberta Vinci was taking on Kaia Kanepi.