A wealthy Queensland property developer has given more than $50 million to medical research in what is believed to be the country's largest single charitable donation.

Clive Berghofer AM of Toowoomba has given the Queensland Institute of Medical Research $50.1 million.

And to show its gratitude, the institute will rename itself the Berghofer Medical Research Institute.

Mr Berghofer will address the media later on Wednesday.

He has previously donated more than $10 million to the institute.