His grim visage has caused havoc in the Marvel universe before.

Now, with Thanos' galactic-domination plans set to play out beyond the printed pages of Marvel comics, the erstwhile villain is back in the six-issue miniseries "Infinity" that blends not just heroes from earth, but also those from beyond the stars and elsewhere in a campaign that threatens Earth, the galaxy and maybe even time and space itself.

Writer Jonathan Hickman says the scale of the book, which was released Wednesday, is such that it's been given an "event" label and it involves many different events, plots, characters, arcs and struggles.

Given Thanos' appearance, that means he and artist Jim Cheung are creating "something that is of consequence."