A 26 year old man has died in a head-on crash at Boyer, north of Hobart.

Paramedics treated four injured people at the scene of the accident involving two cars on Boyer Road, near Norske Skog at 6:30pm.

Police say the dead man was the driver of one of the cars.

The driver of the other car was seriously injured and was taken to the Royal Hobart Hospital, while two passengers from the vehicles suffered minor injuries.

Boyer Road was blocked for about an hour after the accident.

Police will prepare a report for the coroner.