STORY: Four of Hollywood's biggest leading men have joined forces in the new comedy "Last Vegas."

Michael Douglas, 69, Morgan Freeman, 76, Kevin Kline, 66, and Robert De Niro, 70, play best friends who hit Las Vegas to celebrate the impending nuptials of Douglas' character.

For the veteran actors the first day on the set was all about getting comfortable with each other.

"You know this was a unique situation, not one of us had ever done a picture with the other one. Which is, sort of, unique when we sort of realized that. But I think it's - this is the joy of doing movies with older guys. I mean you're comfortable in your own skin. And you don't have anything to prove, you know?" said Douglas.

Actor Jerry Ferrara, best known for his role on the former U.S. cable show "Entourage," plays a nemesis turned friend to the crew of friends in the film.

The film also stars Mary Steenburgen, Romany Malco and a brief cameo by rapper 50 Cent.

"Last Vegas" hits U.S. theaters on November 1.